Publications 2010

Author Title Publication
Bianchi, E., Barbagallo, F., Valeri, C., Geremia, R., Palustri, A., De Felici, M., Sette, C. Ablation of the Sam68 gene impairs fertilità and gonadotropin-dependent follicle development. Human Molecular Genetics (in press).
Valacca, C., Bonomi, S., Buratti, E., Pedrotti, S., Baralle, F.E., Sette, C., Ghigna, C., Biamonti, G. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. Journal of Cell Biology 191, 87-99.
Pedrotti, S., Sette, C. Spinal Muscular Atrophy: a novel player joins the battle for SMN2 exon 7 splicing. Cell Cycle 9, 3874-9.
Busà, R., Sette, C. An emerging role for nuclear RNA-mediated responses to genotoxic stress. RNA Biology 17, 7(4).
Pedrotti, S., Bielli, P., Paronetto, M.P., Ciccosanti, F., Fimia, G.M., Stamm, S., Manley, J.L., Sette, C. The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO Journal 29, 1235-47.
Busà, R., Geremia, R., Sette, C. Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin. Nucleic Acids Research 38, 3005-18.
Paronetto, M.P., Cappellari, M., Busà, R., Pedrotti, S., Vitali, R., Comstock, C., Hyslop, T., Knudsen, K.E., Sette, C. Alternative splicing of the proto-oncogene CCND1 is regulated by Sam68 in human prostate cancer. Cancer Research 70, 229-39.
Paronetto, M.P., Sette, C. Role of RNA-binding proteins in mammalian spermatogenesis. International Journal of Andrology 33, 2-12.
Buratti, E., Chivers, M., Hwang, G., Vorechovsky, I. DBASS3 and DBASS5: databases of aberrant 3’ and 5’ splice sites. Nucleic Acids Research [Epub ahead of print].
Valacca, C., Bonomi, S., Buratti, E., Pedrotti, S., Baralle, F.E., Sette, C., Ghigna, C., Biamonti, G. Sam68 regulates EMT through alternative splicing-activated NMD of the SF2/ASF proto-oncogene. Journal of Cell Biology 191(1), 87-99.
Änkö, M-L., Morales, L., Henry, I., Beyer, A. and Neugebauer, K.M. Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. Nature Structural and Molecular Biology 17, 962-70.
Pabis, M., Neufeld, N., Shav-Tal, Y. and Neugebauer, K.M. Expression and dynamic localization of an alternative isoform of the nuclear cap-binding complex subunit CBP20. Nucleus 1, 412-421.
Huranová, M., Ivani, I., Benda, A., Poser, I., Brody, Y., Hof, M., Shav-Tal, Y., Neugebauer, K.M. and Stanek, D. Differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells. Journal of Cell Biology 191, 75-86.
Pelisch, F., Gerez, J., Druker, J., Schor, I.E., Muñoz, M.J., Risso, G., Petrillo, E., Westman, B.J., Lamond, A.I., Arzt, E., and Srebrow, A. The serine/arginine-rich protein SF2/ASF regulates protein sumoylation. Proceedings of the National Academy of Science USA, [Epub ahead of print].
Llorian, M., Schwartz, S., Clark, T.A., Hollander, D., Tan, L-Y., Spellman, R., Gordon, A., Schweitzer, A.C., de la Grange, P., Ast, G., Smith, C.W.J. Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB. Nature Structural & Molecular Biology, [Epub ahead of print].
Ghigna, C., De Toledo, M., Bonomi, S., Valacca, C., Gallo, S., Apicella, M., Eperon, I., Tazi, J. and Biamonti, G. Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives. RNA Biology 7(4), [Epub ahead of print].
Cherny, D., Gooding, C., Eperon, G.E., Coelho, M.B., Bagshaw, C.R., Smith, C.W.J. and Eperon, I.C. Stoichiometry of a regulatory splicing complex revealed by single molecule analyses. EMBO Journal 29, 2161-2172.
Nlend Nlend, R., Meyer, K. and Schümperli, D. Repair of pre-mRNA splicing: Prospects for a therapy for Spinal Muscular Atrophy. RNA Biology 7(4), [Epub ahead of print].
Ittig, D., Luisier, S., Weiler, J., Schümperli, D. and Leumann, C.J. Improving gene silencing of siRNAs via tricyclo-DNA modification. Artificial DNA 1, 1-8.
Strzelecka, M., Trowitzsch, S., Weber, G., Lührmann, R., Oates, A.C. and Neugebauer, K.M. Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 17, 403–409.
Strzelecka, M., Oates, A.C. and Neugebauer, K.M. Dynamic control of Cajal body number in zebrafish embryogenesis. Nucleus 1, 96-108.
Dreumont, N., Bourgeois, C.F., Lejeune, F., Liu, Y., Ehrmann, I.E., Elliott, D.J., Stévenin, J. Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}. Journal of Cell Science 123, 40-50.