Alternative Splicing and health

With so many genes undergoing alternative splicing in suchImage of a stethoscope intricate and controlled ways it is not surprising that when things go wrong with splicing, diseases can occur. This can either be a mutation in a specific gene which changes the normal splicing or mutations which affect splicing of many genes.

About 15% of mutations connected with disease affect splicing.

 Alternative Splicing when it is altered can cause